Beta138 - What is a Beta Feature?

 

SMAN 10 JAKARTA

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Hemoglobin Brockton [beta 138 (H16) Ala----Pro] is an unstable variant with low oxygen affinity, but does not disrupt critical inter and intrasubunit hydrogen bonds or salt bridges in the beta carboxyl terminus region of hemoglobin.

Features

Beta Features are new functions that can be enabled in Preferences before they're released to everyone. Typically, they're experimental and intended to inspire discussion and provide an alternative to the 138 standard options. A feature becomes a Beta Feature when it meets certain criteria and is approved on the wiki's discussion page.

Hemoglobin Brockton [beta 138 (H16) Ala----Pro] is an unstable variant of Hb A that causes mild anemia. X-ray crystallographic and oxygen affinity data show that the substitution does not disrupt critical inter- and intrasubunit hydrogen bonds and salt bridges in the hemoglobin beta helix, indicating that it is not disruptive to normal oxygen-binding properties.

The CCDC138 gene encodes a protein that contains multiple alpha helixes, beta sheets and coiled-coils. This protein does not have a transmembrane domain.

Recent structures of activin class cytokine receptors have provided foundational knowledge about how they bind different ligands and elicit a range of cellular responses. These structural studies also enabled comparisons between mutated and wild-type receptors to understand how specific mutations alter the kinase activity of each receptor.

The structure of a hemoglobin variant with decreased oxygen affinity, Hb Brockton [beta 138 (H16) Ala----Pro], revealed that substitution of proline for asparagine at position 138 disrupts critical inter and intrasubunit hydrogen bonds that contribute to the cooperative oxygenation mechanism of normal hemoglobin. Hemoglobin variants with similar oxygen affinity, such as Hb Stanmore [beta 111 (G13) Val----Ala], have not been studied to determine the extent of the disruption of these polar interactions. However, both hemoglobin variants show low intrinsic oxygen affinity. Consequently, their clinical consequences are likely similar to that of Hb Brockton.